PhD (Immuno-oncology): Toward valorising cancer immunotherapy

Employer

University of Leuven, Leuven, Belgium

Description

The Laboratory for Cell Stress & Immunity (KU Leuven, Belgium) seeks a highly motivated PhD position Broad Research Topic: Designing and valorising next-generation immunotherapy solutions for immuno-resistant tumours to pave way for near future clinical and industrial immuno-oncology applications Description: This is a unique position for a highly motivated candidate, available at the Laboratory of Cell Stress & Immunity (CSI) in KU Leuven, for a research project at the interface of fundamental translational research and immunotherapy product-oriented valorisation efforts in collaboration with the PharmAbs platform of KU Leuven. This position is embedded in a project that brings together the CSI lab with a translational immunology focus (led by Prof. Abhishek D. Garg), and PharmAbs with an antibody engineering focus (managed by Dr. Nick Geukens). The CSI lab focusses on the following research themes: cancer immunology & immunotherapy, immunology of cancer cell death, immune cell biology, computational immunology, and multi-omics biomarkers for clinical immuno-oncology. The CSI lab aims to specialize in reverse translational approaches to hasten progress in immuno-oncology and help improve therapeutic outlook for cancer patients, in close collaboration with leading researchers, immunologists, and oncologists. PharmAbs is a KU Leuven innovation, valorisation and incubation platform focused on (1) the development of novel antibody discovery and delivery technologies and (2) innovative antibody-based therapeutics and diagnostics. For the current project, PharmAbs’ expertise and technologies will be used to translate basic scientific innovations emerging at our lab into therapeutic solutions for personalized medicine that can be implemented in the clinic and/or commercialized by third parties in near future. This project aims to utilize fundamental and translational insights recently gained on targeting immuno-resistant tumours in the CSI lab and convert these into tangible antibody-based immunotherapies for treating tumours that have failed to response to anti-PD(L)1 or anti-CTLA4 immunotherapies. The project will integrate advanced antibody engineering with immuno-oncology, multi-omics workflows, and translational immunotherapy. With this project we ambitiously aim to go significantly beyond the current state-of-the-art, by creating innovative immunotherapies that would be eventually ready-to-use in a clinic. For more info on CSI lab, see the lab website: https://abhishek-d-garg.wixsite.com/csi-lab For more info on PharmAbs, see their website: https://www.pharmabs.org/

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