Employer
Deparment of Chemistry, University of Hamburg, Hamburg, Germany
Description
We are looking for a highly motivated and talented PhD candidate to join our interdisciplinary research team at the Institute of Physical Chemistry. This position offers the opportunity to conduct cutting-edge research in the field of biohybrid materials.
Our research focuses on the development of functional protein-based materials and the investigation of their synthesis, processing, and performance, for example, for advanced biomedical and biotechnological applications.
In this position, you will focus on protein design for protein-based adsorber materials: designing engineered protein variants with tailored binding properties and validating them experimentally to improve selectivity and material performance.
Within our research group the successful candidate will be responsible for:
Experimental Research
- design and develop engineered protein variants with tailored functional properties using rational design approaches
- perform molecular biology workflows, including recombinant protein production and purification of engineered protein variants
- generate modified protein-based materials and investigate how protein modifications affect material properties and adsorption behavior
- establish and optimize workflows for the quantitative evaluation of material performance in iterative design, testing, and optimization cycles
Functional Evaluation and Data Analysis
- develop and perform quantitative assays to evaluate the functional properties of engineered protein-based materials
- analyze experimental data to relate molecular design to material properties and functional performance, and use the results to guide further optimization
- maintain accurate and detailed records of all research activities and findings
Method Development
- develop and optimize experimental methods for the characterization and evaluation of functional protein materials
- improve and standardize assay workflows to enhance selectivity, reproducibility, and comparability between different material variants
Collaboration and Communication
- work collaboratively within the group and with interdisciplinary project partners, coordinating with colleagues responsible for material synthesis and structural characterization
- present research findings in group meetings, departmental seminars, and international conferences
- prepare manuscripts for publication in peer-reviewed journals and contribute to project reporting across collaborating work packages
Mentoring
- mentor undergraduate and master's students involved in related research projects
Compliance and Safety
- ensure compliance with safety regulations and ethical standards and actively participate in laboratory safety training
Your profile
A university degree in a relevant field.
Candidates are required to have:
- master’s degree (or equivalent) in Chemistry, Biochemistry, Biotechnology, Molecular Biology, Materials Science, or a closely related field
- practical laboratory experience in protein engineering, molecular biology, biochemistry, or related areas
- experience with recombinant protein expression and purification is advantageous
- knowledge of computational protein design and protein redesign approaches (e.g., structure-based design or related computational tools) is highly desirable
- interest in combining computational approaches with experimental validation for the development of functional protein-based materials
- strong analytical thinking and problem-solving skills, with the ability to design, perform, and evaluate experiments independently
- ability to analyze experimental data and derive conclusions to guide iterative optimization strategies
- good organizational skills and the ability to maintain accurate experimental records
- good communication skills and the ability to work effectively in an interdisciplinary research team
- excellent proficiency in English, both written and oral; knowledge of German is beneficial but not mandatory
The successful candidate will have the opportunity to pursue a PhD at the University of Hamburg in Chemistry.
Please mention Science HR when applying
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