About
Summary
I hold MS in Bioengineering and Bioinformatics, and Ph.D. in Molecular Biology.
During the undergraduate and doctorate period I’ve learned to work independently; search, collect and systematize comprehensive information about explored subjects; plan work ahead considering possible risks; find appropriate methods, reagents and equipment; work under stressful and rapidly changing conditions; analyze, interpret, integrate and report the obtained results; write grant applications and reports. At that date I got experience in document management. Supervised work of Ph.D. and Master students. The most significant achievement of the period was the insight – that eventually came to be in PNAS journal – into how p53 sense ETC complex III dysfunction.
Several achievements of postdoc period are development of the project devoted to genetic disorders treatment using viral vectors for pharmaceutical company; mesenchymal stem cells isolation, cultivation and preparation for therapeutic purposes; preclinical trials execution. Concerning the latter having no prior experience in the field I’ve explored regulatory documents and developed a detailed trial designs within a short timeframe, found joint contractors and wrote for them particularized Terms of Reference as part of performance agreements; for one tested substance I’ve found appropriate excipients, permitted for human use, and developed a pharmaceutical formulation for intravenous injection; for both drugs I’ve developed animal models for pharmacodynamics studies; directly participated in diagnostic drug pharmacokinetics study.
Positions
Senior researcher 2014 -
Main Projects:
1) Liver-on-a-chip for drug screening applications;
2) Preclinical trials using standard animal models, and microfluidic organs-on-a-chip.
Research Fellow 2011 - 2015
Research Center for Obstetrics, Gynecology and Perinatology
Referral tasks: Mesenchymal stem cells isolation from different adult and fetal sources, cultivation and preparation for therapeutic purposes.
Junior researcher 2009 - 2014
Laboratory of Molecular Biology of the Gene, Lomonosov Moscow State University
Main research topic: The mechanism of p53 tumor suppressor activation after mitochondrial complex III inhibition.
Education
Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University 2008 - 2012
Field of study: Molecular Biology
Degree: PhD
PhD thesis: Activation of tumor suppressor p53 after electron transport chain complex III inhibition.
PhD in Molecular Biology.
Lomonosov Moscow State University 2003 - 2008
Field of study: Bioengineering and Bioinformatics
Degree: MS
MS thesis: Activation of tumor suppressor p53 after electron transport chain inhibition.
MS in Bioengineering and Bioinformatics with specialization in Bioengineering.
Skills
Primary cells and cell lines cultivation (in statics and microciculation) and manipulation (differentiation, transfection, infection, viral particles production, spheroids formation, impedance-based cell assays, etc) Molecular cloning Bimolecular fluorescence complementation (BiFC), Fluorescence resonance energy transfer (FRET) Confocal fluorescence microscopy Immunocytochemistry, immunoblotting, immunoprecipitation Flow cytometry ELISA Real-time PCR Biochemical assays Basic skills in work with laboratory animals (mice and rats)
Professional interests
At the moment I’m thrilled by the ways the latest scientific and technological developments can be used for the purposes of human health, in particular by regenerative and supportive cell therapy; targeted gene therapy; personalized medicine; organotypic 3D cell culture models for drug screening applications; whole-genome sequencing for screening embryos during in vitro fertilization; drugs development, preclinical and clinical trials.
CV
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