About
Summary
I have 10+ years life science research experience, among which five years of cancer research experience with a broad range of technical expertise, a demonstrated record of accomplished research projects, experience in supervising junior researchers, collaborating with other scientists, and producing publications. As a highly self-motivated and independent researcher, I am especially confident about my knowledge and experience in murine models and histological approaches.
Positions
Postdoc Nov 2011 -
UCSF Benioff Children's Hospital Oakland Research Institute
Investigated the effects of ultraviolet radiation (UVR) and vitamin D3 on cancer prevention and treatment using murine breast cancer and skin cancer models
Generated a novel GEM model deleted for keratinocyte lathosterol 5-desaturase (Sc5d) to study attenuation of UVR-induced D3 synthesis
Utilized global KO and conditional KO mice. Investigated the cells of origin of breast tumors using RFP and YFP-expressing C3(1)Tag mice
Postdoc Sep 2009 - May 2011
Pathology and Laboratory Medicine, University of Pennsylvania
Investigated the effects of urokinase plasminogen activator on murine lung vascular permeability and eNOS activation
Extensively performed cell-based assays (cell permeability, immunoprecipitation, IHC), characterization of cell signaling by WB and by using radiolabeled assay kits, IF, microscopy
Collaborated with chemists to construct, express, purify, and characterize human recombinant proteins using bacterial and mammalian expression systems, FPLC protein purification. Supervised summer scholar student
Staff Research Associate Jan 2008 - Jun 2008
Caughey Lab, University of California San Francisco
Studied the role of mast cells and peptidases released by mast cells in lungs for tissue remodeling, scarring, tumor progression, and innate immune responses
Measured chymase and cathepsin G activity in chymase-spiked serum. Conducted screening of peptide-based substrates against mast cell peptidases. Performed kinetic comparison of peptide-based colorimetric substrates, assessment of concentration of active enzyme and of angiotensin II-generating activity in chymase bound to inhibitors
New opportunities
Open to new opportunities: