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Jayaprakash Kolla

Jayaprakash Kolla

Principal Scientific Manager at Hyderabad

  • Joined: 2015
  • Items posted: 0
  • Profile views: 70

About

Summary

Ph.D. in Biology with 15+ years of pharmaceutical and biotech industry experience, including 12 years in leadership roles spanning oncology, immuno-oncology, inflammation, metabolic disorders, and CNS. Proven record in advancing drug discovery programs from target identification to preclinical candidate nomination. Deep expertise in in vitro assay development, high-throughput screening (HTS), translational models, and IND-enabling studies. Recognized for strategic project leadership, client engagement, and cross-functional team management in CRO and pharma environments.

Positions

Principal Scientific Manager Oct 2022 -

Hyderabad

·       Lead in vitro biology strategy for oncology, immuno-oncology, inflammation, and CNS programs, specializing in PROTACs and targeted protein degradation.

·       Directed assay development from feasibility to hit-to-lead and IND-enabling phases; miniaturized HTS assays to 1536-well formats.

·       Managed client relationships across global biotech/pharma; designed and executed tailored research proposals.

·       Integrated 3D organoid and Organ-on-Chip platforms for disease modeling and preclinical validation.

·       Oversaw cross-disciplinary teams, delivering projects on-time and within budget.

Education

Acharya Nagarjuna University 2005 - 2008

Field of study: Microbiology
Degree: PhD

Bioactive metabolites for diverse biological activities. 

Skills

• In Vitro Biology & Translational Models (2D/3D Organoids, Organ-on-Chip)
• High-Throughput Screening (384/1536-well), Assay Miniaturization
• PROTACs, Molecular Glues, Targeted Protein Degradation Platforms
• Biochemical & Cell-Based Assays (Kinase, GPCR, RNA-binding, Phenotypic)
• Flow Cytometry, Imaging, Immunohistochemistry, Biomarker Platforms
• Drug Discovery Project Leadership – Target to IND-enabling Studies
• CRO & Client Relationship Management
• Regulatory Compliance (US-FDA IND, BSL-2/3, Biosafety)
• Strategic Planning, Proposal Development, Budget Oversight

Professional interests

Advancing drug discovery through innovative in vitro assay development, high-throughput screening, and translational biology approaches across oncology, immunooncology, CNS, inflammation, and metabolic disorders. Passionate about integrating molecular and cell biology techniques with advanced preclinical models (3D organoids, organ-on-chip) to enable target validation, mechanism-of-action studies, and IND-enabling research. Committed to cross-functional collaboration, scientific leadership, and delivering impactful therapeutics from discovery to preclinical candidate nomination.

Keywords: assay development, drug discovery, HTS, in vitro, preclinical development, screening, Translational Research

Contact details

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New opportunities

Open to new opportunities: Yes

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