About
Summary
Leonardo Bruno Federico is graduated in Pharmacy - Qualification in Pharmaceuticals and Medicines by the Federal University of Alfenas (2008), master's degree in Chemistry by the same university and PhD through agreement co-tutelle between the University of São Paulo (USP) and Universidad Granada (UGR) in Sciences and Pharmacy. Federico has two post-doctoral internship, the first at the Faculty of Pharmaceutical Sciences of Ribeirão Preto - USP with the line of research in Planning of new candidates for anti-inflammatory drugs project linked to the CPDI - CRID (Center for Research in Inflammatory Diseases) and the second post-doctoral internship, at the same institution, with the project entitled Computational planning and biological evaluation of new potential inhibitors of malate dehydrogenase present in the cell membrane of Xanthomonas citri subsp. citri, of interest for citrus cancer control in partnership with the Federal University of São Carlos. Federico has been working with Computational Chemistry and Molecular Modeling at the rational drug design and virtual screening (Ligand- and Structure-Based Drug Discovery) of chemical compounds with pharmacological characteristics and has experience as university professor acting as professor of several disciplines in the course of pharmacy and chemistry in four distinct universities. Federico currently is the product safety coordinator developing toxicological and biodegradability studies/ simulations of chemical products used in cosmetics.
Positions
Product safety coordinator May 2021 -
Natura & Co (cosmetic company)
Application of computational studies for toxicity prediction and biodegradability of chemical compounds to determine the safety of new products and upgrade existing products.
Development of workflows simulations for the implementation of new computational studies
Postdoc Mar 2019 - Mar 2021
School of Pharmaceutical Sciences of Ribeirão Preto - FCFRP USP, University of Sao Paulo
We developed this research in partnership with the Laboratory of Biochemistry and Applied Molecular Biology (LBBMM) at the Federal University of São Carlos. We develop new strategies to combat citrus cancer using computational methods for drug development.
Member of a multidisciplinary team which investigates the attachment mechanisms of the bacterium Xanthomonas citri subsp. citri (XAC) causing citrus canker. - Co-supervisor of the master's thesis of the student Mariana Pegrucci who developed new potential compounds for the interaction with the enzyme PMI of XAC.
Participation as co-inventor in the patent application: "USE OF CHEMICAL COMPOUNDS INHIBITING PHOSPHOMANOSIS ISOMERASE FOR THE CONTROL OF CITRIC CANCER AND PHYTOPATHOLOGIES ASSOCIATED WITH THE GENUS XANTHOMONES" - Invited Professor of the Post-Graduation Program in Pharmaceutical Sciences of the Faculty of Pharmaceutical Sciences of Ribeirão Preto to teach the classes of Virtual Screening and Molecular Docking.
Postdoc Jul 2017 - Sep 2018
School of Pharmaceutical Sciences of Ribeirão Preto - FCFRP USP, University of Sao Paulo
I was member of the multidisciplinary team of the Center for Research in Inflammatory Diseases (CRID), which investigates the mechanisms underlying inflammatory diseases to conduct integrative and translational research to identify new therapeutic targets.
We developed several virtual screening strategies in databases of commercial compounds and developed the selection of drug candidates for inflammatory diseases.
Education
University of São Paulo (Brazil) and University of Granada (Spain) 2013 - 2016
Field of study: Pharmaceutical Chemistry
Degree: PhD - Double Degree
Synthesis, anti-proliferative and anti-leishmanial effectiveness, and in silico studies of novel 1,2,3-triazole tethered tri-functional hybrids
Description: The design of modulators of microtubule dynamics leads to a blockage of the cell cycle and is an important strategy for anti-cancer and anti-leishmanial therapies. The use of calcium blockers such as 1,4-dihydropyridines and analogs has shown interesting results in the decrease of chemotherapy resistance in cancer. Moreover, calcium blockers interfere with the adhesion of the parasite to macrophages and can be considered an important strategy to control the initial phase of leishmaniasis. In view of the drug resistance with most of the currently used anti-cancer and anti-leishmanial drugs, three chemical libraries are proposed consisting of molecular hybrids of benzimidazole (or dinitroaniline) and symmetrical 1,4-dihydropyridine functionalities tethered by the 1,2,3-triazole ring to be evaluated for cytotoxic studies against three human cancer cell lines and anti-leishmanial activity. We propose three chemical libraries that comply with Lipinski’s Rule of five rules that predict good oral bioavailability. Click Chemistry, Mitsunobu, and multi-component reactions will be applied for the easy generation of the focused libraries for the synthesis of medicinally relevant anti-tumor and anti-leishmanial agents. This new approach permits optimism in relation to the possibility of obtaining specific and less toxic anti-tumor and anti-leishmanial therapies in the short and long term.
Federal University of Alfenas 2010 - 2013
Field of study: Pharmaceutical Chemistry
Degree: Master
Computational study of new acetylcholinesterase inhibitors, planned as drug candidates for the treatment of Alzheimer's disease
Federal University of Alfenas 2004 - 2008
Field of study: Pharmaceutical Sciences
Degree: Bachelor's Degree
Skills
- Expertise in Ligand- and Structure-based Drug Discovery - Used in virtual screening and hits optimization (hit-to-lead process).
- Domain in the methodologies: molecular docking, molecular dynamics, pharmacophore, QSAR and Machine Learning, shape and electrostatic similarity, ADME/Tox prediction, structural homology of protein, and others.
- Python Programming skills and Knime - Automation script development
Professional interests
I am interested in composing research groups, of any nature, that work with drug development and are interested in professionals with expertise in the use of in-silico tools.
Keywords: cosmetic chemistry, drug discovery, in-silico, pharmaceutical chemistry, postdoc, postdoctoral positionCV
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