NAVANEET CHATURVEDI

Summary

I am working as a Post-Doc Research Associate, University of Leicester, The United Kingdom under mentorship of Prof Dr Geerten Vuister. Vuister’s lab is basically Collaborative Computing Project for NMR (CCPN) group, where I try to generate structure ensembles through computer simulation, that capture the dynamic aspects, thus are suitable for small molecule ensemble docking. Due to COVID19, I am working from home.

Earlier, I was working as a Assistant Professor and Interim-Dean at University of Information Science and Technology, Ohrid, Nort Macedonia. I had responsibility to organise departmental meeting once in a week.

I hold a Ph.D. degree in Bioinformatics from Center of Bioinformatics, University of Allahabad, India. Research is my first love, therefore, I had been a postdoctoral researcher in Structural Biology Research group of Prof Dr Gali Prag, at Department of Biochemistry and Molecular Biology, Tel Aviv University, Israel. (https://www.praglab.org/). Approximately four years in Prag’s lab, my primary research goals had been towards Molecular dynamics simulation with association of experimental work when needed. I have learnd how to perform simulation and to analyze trajectories of system in meaningful manner. My main interest was studying through the interaction of proteins the functionality of complex systems. Using GPUs computations, my first project that I involved in, was The effect of regulating molecules on the structure of the PPAR-RXR complex, which was published in Biochim Biophys Acta in 2016. In the other work, I executed trajectories which advocated a novel bacterial genetic selection system to study protein-protein interactions. Where, we designed a split chloramphenicol acetyltransferase (CAT) fragments are fused in-frame with bait and prey and co-expressed in bacteria. Bait and prey interaction enables assembly of functional CAT giving rise to bacterial growth on selective plates. Before leaving Israel (Sept 2017), This work is under process wet lab test before submission for publication. In Prag’s lab, I also learned wet lab techniques like primer designing, PCR, cloning, transformation, gel-electrophoresis, DNA and protein isolation, protein purification etc.

As a graduate student and then during my postdoc, I undertook projects involving a considerable amount of research on protein-protein and protein-ligand complexes using approaches such as docking, in silico mutagenesis, molecular dynamics simulations, and binding freeenergy calculation. Together with Prag lab, I also worked in the groups of few scientists, for example Prof Dr Yossi Tsfadia and Prof (Emeritus) Menachem Gutman (Tel Aviv University, Israel). I eveloped/extended their techniques to handle last assignment on E6AP system (part of the ubiquitation systems), which is involved in targeting proteins for degradation, was the specific enzyme that I am involved with. I have also synergized my research skills and research interests in my one year (2018-19) on computational biochemistry, I was involved as research assoaciate in lab of Prof Dr Abha Mishra (Indian Iinstitute of Technology-BHU, India) in a renowned institute in India. Where, we have extracted the 4-6 polypheonol compounds from Faba beans plant and tested binding phenomenon computationally and experimentally on alpha-glucosidase and xanthine-oxidase to reduce sugar.

In this view, I would like to emphasize that my field of research considerably meets the interest of your research group. I have experience of Molecular docking, MD simulations, free-energy calculations and necessary wet-lab techniques. I believe that the position will provide me support, challenges and motivation to continue my research work and after completing project, I would establish my own lab back my home country. Enclosed please find my CV, and I would be happy to arrange letters of recommendations. Please let me know if any additional information is necessary to help you come to a decision. I look forward to hearing from you.

Thank you for your time and consideration.

Sincerely,

Navaneet Chaturvedi (PhD)

Positions

Skills

Protein-Protein interaction, Protein-Small-compound interaction, Protein Engineering, Protein
Folding, Structure-Function relationship, Molecular Dynamics, Molecular Modelling, Structure prediction.

CV

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Contact details

New opportunities

Open to new opportunities: Yes