About
Summary
I have just got my Ph.D. degree in July, 2016 in Zoology at Visva-Bharati University, Santiniketan, India in the laboratory of Prof. Santi P. Sinha Babu on the thesis title “Molecular and biochemical evidence of filaricidal activity in botanicals and few derivatives”. During my doctoral thesis tenure we have elaborated the antifilarial activity of different extracts from the leaves of Azadirachta indica in the lights of altered redox status and upregulted apoptosis in model filarial parasites Setaria cervi and Dirofilaria immitis. Antifilarial activity of an important compound Trans-resveratrol along with a series of trans-stilbene derivatives was also evaluated. We found that the induced apoptotic death of exposed parasites was closely associated with the induction of the mitochondrial mediated pathway with altered expressions of apoptogenic proteins. Most interestingly, during assessment of the antifilarial potential of them experimental evidences suggested the probable existence of intrinsic and extrinsic pathways of apoptosis in nematodes which are rare in existing literature.
Before joining Prof. Sinha Babu’s group, I worked in the laboratory of Dr. Shibnath Mazumder in the Department of Zoology at University of Delhi, New-Delhi, India examining of signaling molecules and transcription factors in relation to Mycobacterium sp.
Positions
PhD student Mar 2011 - Jul 2016
• Senior Research Fellow at the Dept. of Zoology, Visva-Bharati University, Santiniketan, India from April, 2013 to January, 2016 with the problem entitled “Molecular and biochemical evidence of filaricidal activity in botanicals and few derivatives”.
• Junior Research Fellow at the Dept. of Zoology, Visva-Bharati University, Santiniketan, West Bengal, 731235, India from Dec. 2010 to March, 2013 with the problem entitled “Molecular and biochemical evidence of filaricidal activity in botanicals and few derivatives”.
• Junior Research Fellow at the Dept. of Zoology, University of Delhi from Oct 2009 to Dec 2010, studied the roll of signaling molecules and transcription factors in relation to Mycobacterium sp.
Education
Visva-Bharati University, Santiniketn, 731235, West Bengal, India 2011 - 2016
Field of study: Parasitology, Zoology, Drug development
Degree: Ph.D.
Thesis title: “Molecular and biochemical evidence of filaricidal activity in botanicals and few derivatives”.
I have just got my Ph.D. degree in July, 2016 in Zoology at Visva-Bharati University, Santiniketan, India in the laboratory of Prof. Santi P. Sinha Babu on the thesis title “Molecular and biochemical evidence of filaricidal activity in botanicals and few derivatives”. During my doctoral thesis tenure we have elaborated the antifilarial activity of different extracts from the leaves of Azadirachta indica in the lights of altered redox status and upregulted apoptosis in model filarial parasites Setaria cervi and Dirofilaria immitis. Antifilarial activity of an important compound Trans-resveratrol along with a series of trans-stilbene derivatives was also evaluated. We found that the induced apoptotic death of exposed parasites was closely associated with the induction of the mitochondrial mediated pathway with altered expressions of apoptogenic proteins. Most interestingly, during assessment of the antifilarial potential of them experimental evidences suggested the probable existence of intrinsic and extrinsic pathways of apoptosis in nematodes which are rare in existing literature.
Skills
• Metazoan parasite culture
• Isolation and culture of filarial parasites
• Isolation of DNA, RNA, different PCR techniques and analysis
• Evaluation of altered redox status through biochemical evaluation of different parameters.
• Different histological techniques of parasites and mammalian tissues
• Fluorescence microscopy
• Western blot, ELISA, FACS analyses
• Apoptotis determination in parasites by different techniques
• Toxicity evaluation of compounds in mammalian system
• Primary pharmacological evaluation of natural products
• Animal handling (Mice, Rat, Dogs etc.)Mammalian cell culture
Professional interests
Basic and applied aspects in parasitology and communicable and non-communicable diseases
Finding and establishment of new pathways of clinical application in disease causing pathogens and manipulation of them and other established pathways to find out new or alternative remedies against them
Pharmacological evaluation of new therapeutics from natural or motivated synthetic compounds against parasitic and metabolic diseases
Explanation of novel pathways in parasitic, communicable and non-communicable diseases
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