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PRASAD ERNALA

PRASAD ERNALA

Main current position is not set

  • Joined: 2025
  • Items posted: 0
  • Profile views: 27

About

Summary

I am a fermentation-based technical leader with 15+ years of end-to-end experience advancing bioactive ingredients — recombinant peptides, functional enzymes, biosurfactants, and bio-based specialty chemicals — from early development through pilot-scale manufacturing and commercial application.

My work sits at the intersection of science, customer success, and commercial execution. I do not just develop processes — I build the application frameworks, team capabilities, and customer-facing technical strategies that translate complex fermentation science into commercially viable, scalable ingredient solutions.

Throughout my career, I have delivered measurable outcomes:

✅ 12x improvement in fermentation-derived ingredient yields across bacterial, yeast, actinomycete, and fungal platforms

✅ ~50% reduction in cost of goods through systematic QbD-driven process development and enzymatic route redesign

✅ Successful technology transfer of multiple GMP processes achieving ≥99% purity at 10,000 L scale

✅ 30% acceleration in client development timelines through structured DoE-based optimization at Verschuren Centre

✅ 2 international patents filed (EP4217503A4 — European Patent Office; WO2022064517A1 — WIPO PCT) on novel fermentation and biocatalytic processes

✅ 7+ peer-reviewed publications in microbial biotechnology and fermentation science

I have built and led cross-functional teams of 10+ scientists and engineers, established application development and technical service frameworks from the ground up, and served as the authoritative technical interface between R&D, manufacturing, quality, and commercial organizations. I understand what it means to be the technical voice of the customer inside a science-driven company.

My fermentation engineering expertise — submerged bioreactor design, fed-batch carbon strategy, oxygen transfer optimization, and integrated downstream recovery — is directly applicable to precision fermentation ingredient platforms including microalgal DHA/omega-3 production systems. I am deeply motivated by the opportunity to apply this expertise to sustainable, commercially viable food and beverage ingredient challenges.

🌍 Currently based in Sydney, Nova Scotia | Permanent Resident — authorized to work in Canada

📍 Open to Director-level roles in Applications & Technical Services, Bioprocess Development, CMC Process Development, and Manufacturing Leadership — locally in Nova Scotia and globally

📩 Let's connect: [email protected]

Positions

Applications & Process Development Lead | Pilot Fermentation & Client Technical Services Mar 2023 - Oct 2025

Sydney-NS

Verschuren Centre for Sustainability in Energy and the Environment (CRO/CDMO)
Sydney, Nova Scotia, Canada | March 2023 – October 2025

Led client-facing application development and technical service programs across bacterial, yeast, and fungal fermentation platforms, translating customer technical requirements into scalable, transfer-ready ingredient and bioprocess solutions for industrial biotechnology and food-grade product clients.

·       Accelerated client program timelines by 30% through structured DoE-based process characterization and optimization, enabling faster application validation and commercial readiness for enzyme, biosurfactant, and bio-based ingredient customers

·       Served as primary technical interface for clients and commercial partners, delivering application strategy recommendations, scale-up risk assessments, and ingredient development roadmaps that directly shaped customer investment and product launch decisions — functioning as the technical voice of the customer within the organization

·       Implemented application documentation frameworks — SOPs, test protocols, batch records, and data integrity systems — ensuring consistent, audit-ready execution aligned with regulatory expectations and CDMO customer transfer requirements

·       Improved ingredient process yields by up to 25% across multiple client programs through upstream optimization and integration of downstream recovery considerations from the earliest development stage

·       Drove continuous improvement in application workflows through Lean Six Sigma and automation integration, increasing pilot facility throughput and on-time delivery across concurrent client programs

·       Designed and delivered Rapid Fermentation Training program (3 cohorts, Upskill Canada-funded), educating and building technical capability in fermentation-based ingredient development across industry and academic audiences — demonstrating ability to communicate complex fermentation science clearly to diverse stakeholders

·       Integrated novel bioprocessing technologies and automation into fermentation workflows, improving process analytical capability and data quality for application characterization studies

Manager, Process & Applications Development | Bioactive Ingredients, Peptides & Enzymes Apr 2017 - Mar 2023

Dr.Reddys

Dr. Reddy's Laboratories Ltd.
Hyderabad, India | April 2017 – March 2023

Led end-to-end applications and process development programs for high-value bioactive ingredients — including recombinant peptides (GLP-1 analogs), functional enzymes, biosurfactants, and specialty bio-based chemicals — across E. coli, yeast, actinomycetes, and fungal platforms, scaling from bench to 10,000 L manufacturing scale.

·       Achieved up to 12x improvement in ingredient yield and ~50% reduction in cost of goods through systematic QbD-driven process development, fed-batch optimization, and enzymatic route redesign — directly enabling commercially competitive pricing and market entry for bioactive ingredient programs

·       Directed technology transfer and application handover to GMP manufacturing partners, ensuring product performance consistency, regulatory compliance, and customer specification alignment at commercial scale — delivering ≥99% purity across key ingredient programs

·       Built and standardized application development frameworks integrating DoE, PAT, and LIMS-driven data systems to enhance process understanding, define control strategies, and improve reproducibility across the applications portfolio

·       Collaborated with commercial and sales teams to develop customer-facing technical documentation, product value propositions, and application guides — enabling sales team effectiveness and accelerating customer adoption of new bioactive ingredient platforms

·       Led structured risk assessments (FMEA) and cross-functional alignment with QA/QC and regulatory teams to ensure compliance with global quality standards and support customer-facing regulatory documentation

·       Accelerated pipeline progression by delivering application development data packages supporting regulatory submissions and customer technical dossiers aligned with global food-grade and pharmaceutical ingredient standards

·       Built and led a cross-functional team of 10+ scientists and engineers, establishing clear performance expectations, development plans, and KPIs — driving execution across multiple concurrent programs and improving on-time milestone delivery

·       Strengthened product lifecycle and commercial positioning through 2 international patent filings (EP4217503A4, European Patent Office; WO2022064517A1, WIPO PCT) covering novel fermentation and biocatalytic processes for high-value bioactive ingredients

·       Filed 2 patents and co-authored 5+ peer-reviewed publications, contributing to innovation pipeline differentiation and IP-led commercialization strategy

Research Fellow — Microbial Biotechnology & Bioactive Ingredient Development Aug 2010 - Apr 2014

Hyderabad

CSIR – Indian Institute of Chemical Technology
Hyderabad, India | August 2010 – April 2014

·       Developed and scaled microbial fermentation and enzymatic processes for bioactive compounds and natural product derivatives, advancing early-stage ingredient programs from lab to pilot readiness

·       Designed and optimized downstream purification processes (IEX, HIC, SEC, affinity chromatography; HPLC/LC-MS validated), enabling high-purity bioactive products suitable for application testing and preclinical evaluation

·       Generated application data packages supporting patent filings and publications, contributing to innovation pipelines and technology differentiation for industrial and specialty ingredient markets

·       Co-authored 5+ peer-reviewed publications in microbial biotechnology and fermentation-derived bioactive compound development

Assistant Manager, R&D — Biotechnology Aug 2008 - Nov 2009

Alkali Metals Ltd.

Alkali Metals Ltd.
Hyderabad, India | August 2008 – September 2009

·       Established a biotechnology R&D function from the ground up — including lab infrastructure build-out, talent recruitment, team training, and development of foundational process capabilities for fermentation and biocatalytic ingredient manufacturing

·       Pioneered early-stage fermentation and enzymatic process development for specialty chemical and bioactive ingredient programs, supporting commercial innovation pipeline

·       Implemented GLP, QA/QC systems, and SOP frameworks, improving data integrity and establishing the technical foundation for future scale-up and regulatory alignment

Education

Osmania University, India 2014 - 2017

Field of study: Microbiology
Degree: Ph.D.

Thesis: Design and Development of Curcumin Bio-conjugates and Their Bioactive Attributes (focus on microbial physiology, enzyme biochemistry, and fermentation-derived ingredients)

Osmania University, India 2006 - 2008

Field of study: Microbiology
Degree: Masters (M.Sc.)

M.Sc., Microbiology — Osmania University, India

Skills

Core Competencies
Applications Development & Technical Services | Customer Technical Support & Solutions | Food & Beverage Ingredient Applications | Fermentation-Derived Bioactive Ingredients | Omega-3 / DHA Platform Awareness | Stage-Gate Process & Portfolio Management | Application Methodology Standardization | Formulation & Stability Support | Technical Sales Enablement | Cross-Functional Program Leadership | IP Strategy & Commercialization | Regulatory Standards (Food-Grade, GRAS, Health Canada) | QbD, DoE & Process Characterization | Fermentation Scale-Up (1 L – 10,000 L) | Upstream & Downstream Integration | Lean Six Sigma (Black Belt) | People Leadership & Team Development | Data Integrity & GLP/GMP Compliance

Keywords: Bioproces techology, design of experiments, downstream process development, Fermentation, interdisciplinary research, Microbial Culturing and their identification, Upstream process development

Professional interests

Director, Applications & Technical Services | Fermentation-Derived Ingredients | Customer-Facing Technical Leadership

Keywords: biochemicals assa, Bioproces techology, Fermentation

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New opportunities

Open to new opportunities: Yes

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