About
Malaria Vaccine Pilot Evaluation-Case Control (MVPE-CC) Project
The MVPE-CC project uses case-control studies to estimate excess risk of meningitis and cerebral malaria, and of mortality in girls, associated with RTS,S vaccination. In addition to these safety signals observed as part of the phase-3 trial, the studies will estimate vaccine effectiveness in preventing severe malaria in children, the importance of rebound effects, and the incremental benefit of receiving the 4th dose of RTS,S. The project also aims to promote the use of case-control approaches by the Expanded Programme of Immunization (EPI) and malaria control programmes in high-burden countries, strengthening their capacity to monitor the safety and effectiveness of malaria vaccines.
MVPE-CC will make important contributions to policy decisions and will help maximize acceptability, uptake and impact, after WHO’s recommendation for widespread use of the RTS,S malaria vaccine among children in sub-Saharan Africa.
TARGET DISEASE: Malaria
TIMELINE: 01 April 2021 to 30 June 2024
COORDINATOR: Kintampo Health Research Centre
FUNDER: EDCTP
FUNDING: € 3.2 Mio
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